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Get Complete Project Material File(s) Now! » Transcriptomics of hypnozoites To date hypnozoite basic biology, mechanistic information regarding hypnozoite formation, persistence and reactivation are not clearly defined. Understanding gene expressions through genetic manipulation-Omics profiling can largely contribute to understanding hypnozoite...
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Get Complete Project Material File(s) Now! » CHAPTER 3 RESEARCH METHODOLOGY INTRODUCTION Research experiences regarding malaria prevention and control and a theoretical model (HBM) that guided the study have been addressed in the second chapter. This chapter presents the research...
Get Complete Project Material File(s) Now! » Global Malaria trends In 2017, an estimated 219 million cases of malaria occurred worldwide (203–262 million)1, an increase of almost two million compared to 2016 and of these, 90% were in the WHO...
Get Complete Project Material File(s) Now! » The statistics Worldwide, there are 109 malaria endemic countries as surveyed in 2008, with 45 of these in Africa. In 2006, 3.3 billion people were at risk of contracting malaria of which 1.2...
Get Complete Project Material File(s) Now! » HISTORY OF MALARIA Symptoms and characteristics of malaria have been documented in historical writings from ancient times [1], such as the Ebers Papyrus from 1570 before Christ (B.C.) [2] and the Chinese medical...
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Get Complete Project Material File(s) Now! » Imidazopyridines (IPs) IP-like scaffolds have been explored as antimalarials and antiprotozoal agents. A potent cGMP-dependent PfPKG inhibitor, ML10 [409], displayed anti-enzymatic (160 pM), asexual stage (IC50 = 2.1 nM) and transmission-blocking (IC50 SMFA...
Get Complete Project Material File(s) Now! » CHAPTER TWO LITERATURE REVIEW Introduction This chapter presents a review of literature based on the study objectives. The first section explores the meaning of evidence and the various types of research categories of...
Get Complete Project Material File(s) Now! » Chapter 3 In vitro identification of inhibitors against PfPdx1 and their potential MOA Introduction On the inner workings of the PLP synthase complex The Pdx1 protein combines R5P and G3P, including ammonia provided...
Get Complete Project Material File(s) Now! » The control of malaria Efforts to control malaria have employed a three-pronged approach involving drug development, vector control and vaccine development, applied separately or in combination (Bathurst and Hentschel, 2006). For example, by...
Get Complete Project Material File(s) Now! » CHAPTER 4 ANALYSIS AND DESCRIPTION OF RESEARCH FINDINGS (PHASE I) INTRODUCTION The previous chapter discussed the research methodology of this study. This chapter deals with data analysis and presents the findings of phase...