DNA damage and mutation in stem and progenitor cells in the context of aging and cancer

Get Complete Project Material File(s) Now! » When protection mechanisms fail: acquisition of mutation Despite the numerous mechanisms in place to protect stem cells from harmful effects of DNA damage, studies over the past 10 years revealed the extent to...

In vitro treatment with DNA methyltransferase inhibitors affected grape berry ripening

Get Complete Project Material File(s) Now! » Numerous histone post translational modifications and histone variants contribute to the epigenetic information All histones are subjected to a wide variety of post translational modifications that include methylation, acetylation, phosphorylation, ubiquitination, and citrullination...

Genetic architecture, bulk segregant analysis, DNA extraction and sequencing

Get Complete Project Material File(s) Now! » Impact of heat stress on plant immunity Heat stress is one of the major abiotic stresses and a main component of climate warming that can affect plant growth and development. A temperature increase...

IMAGING NEURONAL DAMAGE IN THE MS GREY MATTER USING PET WITH [11C]FMZ 

Get Complete Project Material File(s) Now! » Disease-modifying therapies available in 2015 The last 20 years have seen the emergence and systematic use of DMT in MS. There are currently 13 FDA-approved therapies with many more emerging drugs under trial...

Nanomedicines and Ovarian Cancer 

Get Complete Project Material File(s) Now! » High Grade Serous Ovarian Cancer (HGSOC) Risk Factors Ovarian cancer most often affects women between the ages of 75 and 80 years 10,11. Two hypotheses have been suggested to explain the development of...

Atmospheric CO2 concentration, air temperature and water availability

Get Complete Project Material File(s) Now! » ULTRAVIOLET-B (UV-B) RADIATION UV-B RADIATION REACHING THE EARTH Accounting for less than 0.5%, UV-B radiation (280-315 nm) is a minor fraction of the solar radiation reaching the earth surface. This is due to...

THE FUNCTION OF SPECIFIC CATALASES IN PLANTS

Get Complete Project Material File(s) Now! » ROS and Mitogen-activated protein kinase (MAPK) MAPK signaling pathways have been well accepted as a general signal transduction mechanism in eukaryotes. These pathways consist of three functionally linked protein kinases: MAPK, MAPK kinase...

Dithiol disulphide exchange in redox regulation of chloroplast enzymes in response to evolutionary and structural constraints

Get Complete Project Material File(s) Now! » Physcomitrella patens as a Model Organism in Plant Research Choosing the right model organisms in research is crucial for addressing biological questions depending on diverse conditions and aspects. Arabidopsis thaliana (A. thaliana) is...

Role of oxidative stress and inflammation on endothelial dysfunction

Get Complete Project Material File(s) Now! » Inflammation Inflammation is a protective biological response initiated by the immune system that involves complex communication between immune cells to respond to harmful stimuli such as pathogens, damaged cells, or irritants. Acute inflammation...

Distinctive and emerging roles of E2Fs transcription factors during plant replicative stress response

Get Complete Project Material File(s) Now! » Tebichi null mutants display variable developmental defects Previous work reported the phenotype of teb mutants, with stunted growth and deformed leaves (Inagaki et al., 2006). Five alleles of the mutant were initially described,...