Autoinflammation in Behçet’s Disease

Get Complete Project Material File(s) Now! » Behçet’s Disease BD, also known as the Silk Road Disease, is a rare systemic vasculitis disorder of unknown etiology.2,17 While chronic inflammatory disorders are persistent in nature, BD is characterized by recurrent attacks...

Use of psychotropic drugs throughout the course of Alzheimer’s disease : a large-scale study of French medical records

Get Complete Project Material File(s) Now! » Combination of different imaging modalities Multimodality has been put forward in the reviews of AD classification (RA- THORE et al., 2017 ; FALAHATI, WESTMAN et SIMMONS, 2014 ; ARBABSHIRANI et al., 2017). As...

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer’s disease 

Get Complete Project Material File(s) Now! » Structure of FAK family kinases FAK and Pyk2 are composed of three conserved domains (Figure 4): an amino-terminal four-point-one, ezrin, radixin, moesin (FERM) domain, a central kinase domain and carboxy-terminal focal adhesion targeting...

IMAGING NEURONAL DAMAGE IN THE MS GREY MATTER USING PET WITH [11C]FMZ 

Get Complete Project Material File(s) Now! » Disease-modifying therapies available in 2015 The last 20 years have seen the emergence and systematic use of DMT in MS. There are currently 13 FDA-approved therapies with many more emerging drugs under trial...

Muscle contraction activates YAP and NOTCH signalling and thus regulates the pool of muscle progenitor cells during foetal myogenesis Synopsis 

Get Complete Project Material File(s) Now! » Limb muscle formation Limb muscles derive from waves of migrating progenitor cells that reside in the hypaxial lips of the dermomyotomes (Chevallier et al., 1977; Christ et al., 1974). In mouse embryos, the...

A Relation between Schwinger-Keldysh and Feynman generating functionals 

Get Complete Project Material File(s) Now! » Looking inside a proton, first part Our story begins with a close look of a proton at rest. This proton at rest is formed by three quarks (2 u and 1 d), as...

Human RBC membrane in disease 

Get Complete Project Material File(s) Now! » Anion conductance of the human red cell is carried by maxi-anion channel (Blood Cell, Molecules and Diseases, 2010). Edyta Glogowska, Agnieszka Dyrda, Anne Cueff, Guillaume Bouyer, Stéphane Egée, Poul Bennekou, Serge L.Y. Thomas....

Sensory neurons detect pneumococci and promote survival in central nervous system infection

Get Complete Project Material File(s) Now! » A recent discovery: the cerebrospinal fluid-contacting neurons form an interoceptive system in the spinal cord The cerebrospinal fluid (CSF) is a physiological fluid circulating throughout the different brain ventricles, the subarachnoid space and...

Evaluation of the role of lymphocytes in remyelination and defining the molecular basis for an efficient myelin repair in patients.

Get Complete Project Material File(s) Now! » Linking genotypes to MS susceptibility and severity After the discovery of several susceptibility variants for MS, attempts were made to link the genotype of patients with their phenotype to predict disease course and...

Epstein-Barr virus BALF0/1 protein in patients with nasopharyngeal carcinoma

Get Complete Project Material File(s) Now! » EBV-associated human diseases EBV is a ubiquitous lymphocrytovirus which persistently infects more than 95% of population worldwide. EBV is mainly transmitted by saliva and establishes lifelong infection. Whereas EBV persistent infection is usually...