Prevention or treatment of bleeding episodes in patients with hemophilia A 

Get Complete Project Material File(s) Now! » Life cycle of FVIII, catabolic receptors, in vivo distribution. Once released in the circulation, FVIII rapidly associates with VWF (Vlot et al., 1995; Dimitrov et al., 2012). The VWF-FVIII interaction increases FVIII half-life...

Prediction of drug pair forming an “evolutionary trap” for breast cancer

Get Complete Project Material File(s) Now! » Robustness and Evolvability of a Heterogeneous Cell Populations While the model introduced in the Chapter 2 allowed us to explain the experimentally observed relative fitness distributions across stress environments for aneuploid yeast, its...

Calculated ventilation and effort distribution as a measure of respiratory disease and Heliox effectiveness

Get Complete Project Material File(s) Now! » Zero-dimensional tree coupled to a three-dimensional parenchyma In [41], the authors describe the parenchyma as a porous medium irrigated by a space-filling resistive tree. Energy dissipation within airways makes it harder to pull...

Dynamic Exchange Reactions with Imines and Aldehydes 

Get Complete Project Material File(s) Now! » Materials relying on association/dissociation of reversible covalent bonds Dissociative systems were reported using a variety of reversible covalent reactions, such as Diels-Alder (DA), thioesters, dynamic urea bonds, Schiff’s bases, boronic esters and boroxines.21-32...

Quantum Dot-DNA Conjugates for Controlled Assembly of Transferrin 

Get Complete Project Material File(s) Now! » Purification of conjugates of QD-DNA The search for ideal method of purification of functionalized QDs from the excess reactants is as old as the hunt for best strategy of conjugation. Almost no biological...

Physiological Functions of ependymal cells in brain

Get Complete Project Material File(s) Now! » EJC dependent regulation of splicing in human cells In human cells, EJC components (eIF4A3, Y14, Acinus, SAP18 and RNPS1), rather than the assembled complex function as regulators of splicing of apoptosis regulator BCL‐X...

Taxonomic bias in biodiversity data and societal preferences

Get Complete Project Material File(s) Now! » Working on biodiversity patterns: delving into ecoinformatics Cleaning data Systematics and Ecology are now data-intensive sciences. But “Big Data” does not necessarily mean better data (Boyd and Crawford 2012). Data quality must be...

Dysregulated equilibrium between pathogenic and regulatory T cells leads to immune disease

Get Complete Project Material File(s) Now! » mTOR integrates multiple signals during T cell activation The differentiation of naïve CD4 cells into specific Th cell type in vivo is a complex process which requires these cells to integrate various environmental...

Pathological Walking Patterns among Cerebral Palsy Children

Get Complete Project Material File(s) Now! » Gait Spatio-Temporal Parameters Spatio-temporal parameters, as its name indicates, can be divided into two categories: the step parameters, related to spatial configuration, and the time related parameters. Spatial parameters The spatial parameters are...

Deriving the static transfer function and the dynamical transfer function for the IF neuron

Get Complete Project Material File(s) Now! » Bridging spiking neuron models and rate models Spiking neuron models offer insight into dynamics of local networks whereas neural rate models provide an insight into the global activity of networks. Both types of...